I've been rolling full Destro, messing about in 10 and 25 mans with this rotation: Curse of Elements, Corruption, Immolate, Chaos Bolt, Incinerate until Immolate is almost out, Conflag, Shadowbolt x 3, and repeat. I have pretty terrible gear and thats 1400dps for me on most bosses. the inclusion of the 3 shadowbolts is justified to myself by the fact that a) I'm not wasting a Backdraft proc on immolate, b) my shadowbolts still hit for roughly the same, sometimes more than an incinerate does and c) the combination of corruption ticking and the 3 shadowbolts is enough to see Molten Core active for most of the time.

@ Ivan

If incinerate is in flight you can safely conflag. You still get the bonus damage on your incinerate.

I'm 0/52/19 (demon/destro) and I must say, I am enjoying the hell outta it, and have increased my dps output by a lot. I used to be aff/demon, but since switching, for raids, I have been consistently a useful dps, usually topping the dps charts simply because of metamorphosis. Although, I think Locks should play whatever's clever: whatever they find the most joy in, because the better you're tuned with your class and spec, the better you'll be, and I really believe that.

P.S. Affliction WAS super fun!