Loving the Naga. Best thing I bought since my Logitech G13 (which replaced a dying Nostromo N52). I believe on a full hands-on control scheme that requires absolutely minimal keyboard contact (the HOTAS/Cougar spoiled me, what can I say).

I had a different experience to most people with the Naga, I picked up the thumpad almost immediately and have had no problems. I'm playing a Rogue and a Feral Druid (Switching between cat and bear very regularly). Here's the keys I use:

1. Vent PTT
2. Jump (I love having jump bound on the mouse. It seems 'right')
3. Cat/Flight toggle
4. Opie Quest Item Ring
5. Autorun (this key will wear out faster than every other, I promise you).
6. Bear/Flight toggle (can you tell I don't like caster form?)
7, 8, 9. Three more Opie Rings

I don't use the bottom row at all, nor the two extra 'face' buttons.

The Logitech's thumbstick is my movement, and the keys are bound to all sorts of ability macros. My UI has only a small segment of buttons visible, mainly so I can see their cooldown counters. Almost nothing on my UI is 'clicked'.