First, DON'T MOUSE MOVE. Use the Dpad on the N52te for movement (Fwd/Back/Strafe Left/Strafe Right). Use the mouse for fine steering using just the right click. This way the mouse is free for target selection, dropping distraction, etc while your left thumb controls your feet. With this I can drop Distract on one side of a target while circling around to where his back will be.
Just make sure to disable the diagonals on the Dpad and it will work fine whatever you have bound. Personally, I prefer leaving the default North/South, East/West values, as those translate to the cursor arrows. If for some reason you have a chat panel open, those aren't captured by the dpad and you won't send someone a "Wasssddsdsswwwss crap i'm dead" message. (Prat and Chatter have options for scrolling through past messages using the arrows.. disable those if you plan on using them for movement.. more chatfrag)

Now for my blatant plug - check out my youtube channel, The 2 Ring (www.youtube.com/user/grendalsh) for vids on setting up and configuring the N52te for WoW, with profiles for most classes (including rogue).