I also have this mouse! I'm a somewhat petite woman, so I'm assuming I have relatively small hands? (6.5 inches from wrist line to tip of middle finger). Even so, I've found this mouse to be quite nice. I also tend to hold my mice from the back with my wrist on the pad, so keep that in mind. The vertical thumb buttons are real easy for me to use, as is the closer horizontal one, though the further one is a bit harder for me to reach. The pinky button I can hit , though just the back 3rd or so of the button, so I have to press it harder than normal to get it to click. If I rest my hand more on top of my mouse, I can reach all the buttons well enough.

It does move real smoothly though, and has great sensitivity. I also like the glow (I set it to blue). I picked out the mouse not because it's an mmo/WoW mouse, but because it just felt really nice and comfortable in my hand as compared to others at the store. :) Also, if you're the type to care about such things, the packaging in came in was *really* nice. :)

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