Spine is relatively simple, probably more of a healing and burst dps check than anything else.

One thing you can try is to tank the bloods near the front, where you blow up the plate, and tank the amalgamation at the back. The blood tank can AoE down the bloods, and when the amalgamation is low and there are enough blood up front, just run it up there and kill it quick. Beats running it around to pick up the blood at the back, then dragging it back through the raid while pulsing.

Also, if you have a rest shaman, spirit link totem is awesome when 2 or 3 people have searing plasma debuff, like about the time you're doing a roll to knock extra amalgamations off.

One last trick: if you're not getting the tendons down in one shot, you'll eventually get overrun with blood, since you can't knock them off like the amalgamations. However, when you're going to knock amalgamations off, use them to soak up 5-7 puddles before rolling, and you can effectively remove those extra blood (easily 10-15 at a time since you're usually knocking off 2-3 amalgamations) from the back. We did that the first couple of weeks and it helped quite a bit. We can usually blow up a tendon in a single try now so we don't need to do this anymore.

And one last thing...if you don't kill a tendon in a single try, make absolutely sure the next amalgamation explodes on the same side you tried before, so you expose the same damaged tendon.