Here's some suggestions I've come up with in my time playing every spec of every class:

1. Rogues = tanks. This is major. Evasion tanking from BC was just boss, and I still try and do it in Cata (To some success, except on raid bosses). Combat tree can do it with prolongued mitigation and cooldowns, and Sub through active cooldown stacking.

2. Warlocks = tanks or healers. Tanks because... well demonology's demon form was asking for it. Throw in a talent that makes demon form permanent at a cost, and gives additional threat like changing stances, and you're set. Healing... well someone could do a sort of sado-masochist blood mage that deals damage to heal others, or hurts himself or others to heal others (trading health points essentially for a cooldown)

3. Melee hunter. It's been tried many times throughout WoW, but simply never managed to work. And with MoP removing the melee weapon slot for hunters, doubtful we'll see it. Still, I could definitely see the survival hunter tree taking advantage of that, as survival generally means "Survive by any means necessary"

4. Tanking shaman. Well let's see... they can use shields, they have a weapon buff that, when combined with unleash element, causes a taunt. So... this could be something for enhancement.
I don't think I'd see a rogue using a two handed weapon. The blademaster essentially became the arms warrior. However, I do think they could bring two handed weapons to the forefront in other classes, such as the shaman, or heck, a hunter.

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