I've played a fair bit of League of Legends, and more recently quite a bit of SMITE, and I enjoy both games, and the MOBA genre as a whole. Blizzard is, I should mention, apparently keen to get away from calling this a MOBA, and move towards the idea of a "Hero Brawler". There are several important differences between the mechanics of Heroes compared to League, particularly, which I really think are fantastic shifts away from a bloated system.
Talents over Item Shop
Now I will not pretend for a second that I am a pro League of Legends player. Heck, I'm probably not even a good one. I got into LoL very late, very late indeed, and there are a couple of elements that have stood in my way as a newer player. The item shop is definitely one of those elements. Even since the introduction of the Shopping List system, and with the Recommended Items list, it's confusing when you're just getting started. Working out what you need and knowing what's good are second nature to a seasoned player, but tricky to a beginner.