We've seen WoW played with a Wii controller before, but this looks like a really serious effort to get the Xbox 360 controller compatible with our favorite MMO. A company called Blue Orb Software has released an app called Switchblade, a free download that lets you use your PC-enabled Xbox 360 controller specifically to play World of Warcraft.
Why would you want to do this? Their press release cites gamers "hooked on the console experience," and so their controller will let you play WoW console style. You can see the basic settings on their site-- it looks like the left and right triggers are used as toggles, turning the four action buttons into 12, and allowing you to use any icon on one of the action bars in WoW. Probably not quite versatile enough for running PvP, but for running daily quests and grinding, it looks just crazy enough to work.
The download is available through Xfire (and it looks like you need to download Xfire to get Switchblade), and the program should work with any wired Xbox 360 controller (if you have a wireless only, you'll have to buy an extra receiver from Microsoft). I think I've got a wired controller sitting around here somewhere, so I'll give it a try and get back to you on how it works. In the meantime, someone download it, and let us know in the comments-- is it worth installing this thing to play WoW with buttons and joysticks?